ATP5F1D

Across TCGA pan-cancer cohorts, ATP5F1D RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ATP5F1D data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher ATP5F1D RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP5F1D expression acts as an unfavorable survival marker, although some lineages such as KIRP and MESO show a favorable association.

UCS, KIRP, and ACC are the cancer types where ATP5F1D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	IV	0.367	0.952	.001	78	view →
KIRP	DFS	Tertile	II,III,IV	0.940	0.230	.001	75	view →
ACC	OS	Quartile	All	0.708	0.967	.001	53	view →
LUAD	OS	Quartile	II,III,IV	0.613	0.810	.006	47	view →
KICH	OS	Tertile	III,IV	0.689	1.000	.002	39	view →
COAD	OS	Median	IV	0.333	0.740	<.001	29	view →
LAML	DFS	Quartile	All	0.274	0.513	.003	28	view →
PRAD	DFS	Quartile	All	0.843	0.953	.003	18	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	17	view →
MESO	DFS	Median	All	0.638	0.258	.002	15	view →
BLCA	DFS	Median	II,III,IV	0.561	0.455	.013	10	view →
UCEC	DFS	Tertile	All	0.820	0.650	.005	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ATP5F1D–UCS (DFS)

Open the UCS breakdown →