ATP5F1D

Across TCGA pan-cancer cohorts, ATP5F1D RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ATP5F1D’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ATP5F1D RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATP5F1D is over-expressed in tumor, although a few such as THCA and HNSC show the opposite, repressed pattern.

LUSC, LIHC, and KICH are the cancer types where ATP5F1D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP5F1D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	+0.659	<.001	6	view →
LIHC	Female	All	+0.952	<.001	4	view →
KICH	Female	II,III,IV	+0.595	<.001	4	view →
CHOL	Female	All	+0.893	.014	2	view →
STAD	All	IV	+0.786	.006	2	view →
THCA	Male	II,III,IV	−0.507	.016	2	view →
UCEC	All	All	+0.420	.020	2	view →
LUAD	Female	III,IV	+0.408	.014	2	view →
HNSC	Female	III,IV	−0.513	.036	1	view →
COAD	Female	All	+0.449	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ATP5F1D–LUSC

Open the LUSC breakdown →