ATP5F1C

Across TCGA pan-cancer cohorts, ATP5F1C mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ATP5F1C data layer compared with 30 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ATP5F1C mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ATP5F1C expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LSCC, and GBM are the cancer types where ATP5F1C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.601	0.383	.008	20	view →
LSCC	OS	Median	All	0.983	0.790	.001	19	view →
GBM	OS	Tertile	All	0.878	0.701	.015	3	view →
LUAD	DFS	Tertile	All	0.484	0.752	.043	3	view →
HNSC	DFS	Quartile	II,III,IV	0.867	0.964	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ATP5F1C–PDAC (OS)

Open the PDAC breakdown →