ATP5F1C

Across TCGA pan-cancer cohorts, ATP5F1C RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ATP5F1C’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where ATP5F1C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATP5F1C is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

LIHC, THCA, and KICH are the cancer types where ATP5F1C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP5F1C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	All	+0.881	<.001	9	view →
THCA	Male	III,IV	−0.564	<.001	9	view →
KICH	All	All	−0.744	<.001	7	view →
LUSC	Female	All	+0.659	<.001	7	view →
BLCA	All	All	+0.481	.003	7	view →
KIRC	Male	II,III,IV	−0.460	<.001	7	view →
UCEC	All	II,III,IV	+0.533	.008	6	view →
BRCA	All	All	+0.416	<.001	6	view →
LUAD	Male	All	+0.451	<.001	5	view →
HNSC	All	All	−0.197	.013	4	view →
CHOL	Female	All	+1.883	<.001	3	view →
STAD	All	All	+0.297	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ATP5F1C–LIHC

Open the LIHC breakdown →