ATP5F1C

Across TCGA patient cohorts, ATP5F1C mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP5F1C-associated genes across cancer lineages are EGFR_pY1068, ATM, and Ku80. Each is linked with ATP5F1C in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP5F1C-to-partner and partner-to-ATP5F1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ATP5F1C-low versus ATP5F1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP5F1C→partner) and Y-score (partner→ATP5F1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.281	-2.584	.016	.011	3	2
UCEC	ATM →	-0.691	-2.584	.001	.011	3	2
UCEC	Ku80 →	+0.296	+2.598	.007	.006	3	1
UCEC	Notch1 →	+0.233	+3.335	<.001	.005	3	1
UCEC	P-Cadherin →	-0.145	-3.159	.031	.019	3	1
UCEC	PDCD4 →	-0.613	-2.990	.005	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1068 by ATP5F1C expression — UCEC

Explore this box plot interactively →