ATP5F1C

Across TCGA cell cohorts, ATP5F1C RNA expression is significantly associated with the go_rna of many other GO terms, with 3,332 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ATP5F1C-associated GO terms across cancer lineages are 'de novo' cotranslational protein folding, Positive regulation of mitochondrial ATP synthesis coupled electron transport, and Purine deoxyribonucleoside monophosphate biosynthetic process. Each is linked with ATP5F1C in more than 11 cancer types. Because this analysis shows association rather than direction, both ATP5F1C-to-partner and partner-to-ATP5F1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 'de novo' cotranslational protein folding grouped by ATP5F1C-low versus ATP5F1C-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP5F1C→partner) and Y-score (partner→ATP5F1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	'de novo' cotranslational protein folding →	+0.167	+0.746	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.140	+1.218	<.001	<.001	3	11
LARGE_INTESTINE	Purine deoxyribonucleoside monophosphate biosynthetic process →	+0.103	+0.564	<.001	<.001	2	11
LARGE_INTESTINE	DAMP biosynthetic process →	+0.103	+0.564	<.001	<.001	2	11
CNS	Ubiquinone biosynthetic process →	+0.088	+0.705	<.001	<.001	3	9
BLOOD_Myeloma	Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.155	+1.351	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,332 associations by consensus.

'de novo' cotranslational protein folding by ATP5F1C expression — LARGE_INTESTINE

Explore this box plot interactively →