ATP5F1B

Across TCGA pan-cancer cohorts, ATP5F1B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ATP5F1B data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ATP5F1B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP5F1B expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where ATP5F1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.524	0.749	.010	8	view →
LUAD	DFS	Median	All	0.435	0.724	.008	5	view →
PDAC	DFS	Quartile	All	0.505	0.317	.020	4	view →
CCRCC	OS	Median	All	0.985	0.674	.039	3	view →
LSCC	OS	Tertile	II,III,IV	1.000	0.887	.043	2	view →
GBM	OS	Quartile	All	0.888	0.761	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ATP5F1B–HNSC (DFS)

Open the HNSC breakdown →