ATP5F1B

Across TCGA patient cohorts, ATP5F1B mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP5F1B-associated genes across cancer lineages are MEK1, Notch1, and PAI-1. Each is linked with ATP5F1B in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP5F1B-to-partner and partner-to-ATP5F1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ATP5F1B-low versus ATP5F1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP5F1B→partner) and Y-score (partner→ATP5F1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.485	+3.000	.015	.036	3	2
UCEC	Notch1 →	+0.161	+2.817	.037	.036	3	1
UCEC	PAI-1 →	+0.435	+3.169	.021	.020	3	1
UCEC	Paxillin →	+0.315	+2.817	.027	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+1.005	+3.019	.001	.019	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MEK1 by ATP5F1B expression — UCEC

Explore this box plot interactively →