Across TCGA pan-cancer cohorts, ATP5F1AP8 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of ATP5F1AP8’s most consistent transcriptional readouts.
The strongest signal is observed in esophageal carcinoma (ESCA), where ATP5F1AP8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATP5F1AP8 is over-expressed in tumor.
ESCA are the cancer types where ATP5F1AP8 tumor–normal differential expression is most reproducible.