ATP5F1A

Across TCGA pan-cancer cohorts, ATP5F1A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ATP5F1A data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ATP5F1A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ATP5F1A expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LUAD, and LSCC are the cancer types where ATP5F1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.611	0.398	.009	19	view →
LUAD	DFS	Median	All	0.451	0.728	.012	6	view →
LSCC	OS	Median	All	0.954	0.819	.036	3	view →
CCRCC	OS	Median	All	1.000	0.763	.039	1	view →
GBM	OS	Quartile	All	0.913	0.777	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ATP5F1A–PDAC (OS)

Open the PDAC breakdown →