ATP5F1A

Across TCGA patient cohorts, ATP5F1A mutation is significantly associated with the RNA expression of many other genes, with 2,075 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP5F1A-associated genes across cancer lineages are MIR3159, OR52E2, and RNU6-1107P. Each is linked with ATP5F1A in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP5F1A-to-partner and partner-to-ATP5F1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3159 grouped by ATP5F1A-low versus ATP5F1A-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP5F1A→partner) and Y-score (partner→ATP5F1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR3159 →	+0.413	+5.368	.001	.005	3	3
HNSC	OR52E2 →	+0.057	+6.221	<.001	.001	3	2
HNSC	RNU6-1107P →	+0.332	+6.339	<.001	.001	3	2
HNSC	MIR569 →	+0.336	+5.182	<.001	.007	3	2
READ	RNU6-197P →	+0.836	+5.039	<.001	.008	3	2
UCEC	TRAJ21 →	+0.435	+2.181	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,075 associations by consensus.

MIR3159 by ATP5F1A expression — HNSC

Explore this box plot interactively →