ATP5F1A

Across TCGA patient cohorts, ATP5F1A mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP5F1A-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and ERK2. Each is linked with ATP5F1A in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP5F1A-to-partner and partner-to-ATP5F1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ATP5F1A-low versus ATP5F1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP5F1A→partner) and Y-score (partner→ATP5F1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.810	+2.169	<.001	.003	3	2
UCEC	14-3-3_beta →	-0.107	-3.432	.004	.005	3	1
UCEC	ERK2 →	+0.285	+2.662	<.001	<.001	3	1
UCEC	GATA6 →	-0.151	-1.700	.009	.042	3	1
UCEC	JNK_pT183_Y185 →	-0.180	-2.584	.004	.010	3	1
UCEC	JNK2 →	+0.400	+3.321	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Caspase-7-cleavedD198 by ATP5F1A expression — UCEC

Explore this box plot interactively →