Across TCGA patient cohorts, ATP4B mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP4B-associated genes across cancer lineages are eEF2, MEK1, and PCNA. Each is linked with ATP4B in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP4B-to-partner and partner-to-ATP4B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP4B→partner) and Y-score (partner→ATP4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.310	+1.584	.027	.036	3	2
UCEC	MEK1 →	+0.337	+1.584	.019	.036	3	2
UCEC	PCNA →	+0.169	+2.000	.046	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.817	+3.321	<.001	.009	3	2
UCEC	EGFR_pY1068 →	-0.207	-2.000	.036	.010	3	1
UCEC	Notch1 →	+0.122	+2.183	.028	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

ATP4B survival (RNA) · tumor vs normal (RNA) · all ATP4B data types