ATP2C1

Across TCGA patient cohorts, ATP2C1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP2C1-associated genes across cancer lineages are ATM, 4E-BP1, and eIF4E. Each is linked with ATP2C1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP2C1-to-partner and partner-to-ATP2C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ATP2C1-low versus ATP2C1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP2C1→partner) and Y-score (partner→ATP2C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.518	-2.432	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.304	+2.444	<.001	.001	3	3
UCEC	eIF4E →	+0.180	+1.836	.006	.001	3	2
UCEC	FoxM1 →	+0.248	+2.115	.002	<.001	3	2
UCEC	Ku80 →	+0.203	+1.366	.006	.010	3	2
UCEC	Notch1 →	+0.193	+1.939	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ATM by ATP2C1 expression — UCEC

Explore this box plot interactively →