ATP2C1

Across TCGA cell cohorts, ATP2C1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,834 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATP2C1-associated GO terms across cancer lineages are Positive regulation of Golgi to plasma membrane protein transport, Regulation of early endosome to late endosome transport, and Endosomal transport. Each is linked with ATP2C1 in more than 13 cancer types. Because this analysis shows association rather than direction, both ATP2C1-to-partner and partner-to-ATP2C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of Golgi to plasma membrane protein transport grouped by ATP2C1-low versus ATP2C1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP2C1→partner) and Y-score (partner→ATP2C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Positive regulation of Golgi to plasma membrane protein transport →	+0.130	+0.733	<.001	<.001	3	14
BREAST	Regulation of early endosome to late endosome transport →	+0.129	+0.734	<.001	.001	3	11
SOFT_TISSUE	Endosomal transport →	+0.052	+0.728	<.001	<.001	3	11
BLOOD_Myeloma	Postsynapse to nucleus signaling pathway →	+0.150	+1.053	<.001	.002	3	10
BONE	Epithelial cell development →	+0.105	+0.712	.006	.002	3	10
LUNG_NSCLC_LUAD	Endocytic recycling →	+0.064	+0.637	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,834 associations by consensus.

Positive regulation of Golgi to plasma membrane protein transport by ATP2C1 expression — OVARY

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