ATP2C1

Across TCGA cell cohorts, ATP2C1 mutation is significantly associated with the mutation status of many other genes, with 1,995 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP2C1-associated genes across cancer lineages are SEL1L2, ITGA5, and ZNF197. Each is linked with ATP2C1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP2C1-to-partner and partner-to-ATP2C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEL1L2 grouped by ATP2C1-low versus ATP2C1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP2C1→partner) and Y-score (partner→ATP2C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SEL1L2 →	+4.977	+4.415	.007	.007	1	4
LUNG_SCLC	ITGA5 →	+5.066	+4.502	.007	.007	1	3
LUNG_SCLC	ZNF197 →	+5.066	+4.502	.007	.007	1	3
LUNG_NSCLC_LUAD	GABRG1 →	+4.772	+5.339	.004	.004	1	3
LARGE_INTESTINE	MAP3K9 →	+3.137	+3.807	.001	.001	1	3
CNS	TOX3 →	+4.614	+4.614	.006	.006	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,995 associations by consensus.

SEL1L2 by ATP2C1 expression — OVARY

Explore this box plot interactively →