ATP2B3

Across TCGA patient cohorts, ATP2B3 mutation is significantly associated with the RNA expression of many other genes, with 5,034 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP2B3-associated genes across cancer lineages are CHEK1, UBE2T, and E2F2. Each is linked with ATP2B3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ATP2B3-to-partner and partner-to-ATP2B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK1 grouped by ATP2B3-low versus ATP2B3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP2B3→partner) and Y-score (partner→ATP2B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CHEK1 →	+0.581	+3.357	.002	.004	3	5
LUAD	UBE2T →	+0.700	+2.825	.002	.001	3	4
UCEC	E2F2 →	+0.538	+1.347	<.001	<.001	3	4
LUAD	NDC80 →	+0.700	+3.596	.002	.001	3	4
STAD	ORC1 →	+0.655	+3.359	.003	.004	3	4
LUAD	OIP5 →	+0.858	+3.723	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,034 associations by consensus.

CHEK1 by ATP2B3 expression — LUAD

Explore this box plot interactively →