ATP2A2

Across TCGA patient cohorts, ATP2A2 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP2A2-associated genes across cancer lineages are 4E-BP1, p90 RSK_pT359_S363, and eEF2. Each is linked with ATP2A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP2A2-to-partner and partner-to-ATP2A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ATP2A2-low versus ATP2A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP2A2→partner) and Y-score (partner→ATP2A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.310	+2.199	<.001	.001	3	3
SKCM	p90 RSK_pT359_S363 →	+0.162	+2.115	.028	.018	3	2
UCEC	eEF2 →	+0.262	+1.584	.015	.032	3	2
UCEC	eIF4E →	+0.178	+3.013	.005	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.159	-1.765	.001	.013	3	2
UCEC	NF2 →	+0.172	+1.584	.008	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

4E-BP1 by ATP2A2 expression — UCEC

Explore this box plot interactively →