ATP2A2

Across TCGA pan-cancer cohorts, ATP2A2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ATP2A2 data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ATP2A2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP2A2 expression acts as an unfavorable survival marker, although some lineages such as UCS and SCLC show a favorable association.

UVM, MESO, and ACC are the cancer types where ATP2A2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.427	0.746	<.001	117	view →
MESO	OS	Tertile	III,IV	0.409	0.686	<.001	101	view →
ACC	DFS	Median	II,III,IV	0.178	0.604	<.001	62	view →
HNSC	OS	Quartile	III,IV	0.547	0.859	.005	49	view →
UCS	DFS	Median	II,III,IV	0.562	0.157	.002	38	view →
PAAD	DFS	Quartile	II,III,IV	0.243	0.596	<.001	29	view →
SCLC	DFS	Median	II,III,IV	0.766	0.257	.009	17	view →
KIRC	DFS	Tertile	All	0.754	0.525	.014	17	view →
BLCA	DFS	Quartile	All	0.173	0.567	.015	17	view →
LIHC	DFS	Median	All	0.485	0.614	.008	16	view →
CESC	DFS	Quartile	All	0.464	0.772	.008	16	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ATP2A2–UVM (DFS)

Open the UVM breakdown →