ATP2A2

Across TCGA cell cohorts, ATP2A2 mutation is significantly associated with the RNA expression of many other genes, with 578 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP2A2-associated genes across cancer lineages are C16orf90, OR2A2, and EIF3L. Each is linked with ATP2A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP2A2-to-partner and partner-to-ATP2A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf90 grouped by ATP2A2-low versus ATP2A2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP2A2→partner) and Y-score (partner→ATP2A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	C16orf90 →	+0.017	+4.087	<.001	.009	3	1
URINARY_TRACT	OR2A2 →	+0.035	+4.087	<.001	.009	3	1
LARGE_INTESTINE	EIF3L →	+0.659	+3.389	<.001	.001	3	1
LARGE_INTESTINE	DEPDC5 →	+0.711	+3.502	<.001	.001	3	1
LARGE_INTESTINE	SAMM50 →	+0.505	+3.234	.003	.004	3	1
LARGE_INTESTINE	TRMU →	+0.674	+3.502	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 578 associations by consensus.

C16orf90 by ATP2A2 expression — URINARY_TRACT

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