ATP1B4

Across TCGA patient cohorts, ATP1B4 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP1B4-associated genes across cancer lineages are ERK2, IGFBP2, and ACVRL1. Each is linked with ATP1B4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP1B4-to-partner and partner-to-ATP1B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ATP1B4-low versus ATP1B4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP1B4→partner) and Y-score (partner→ATP1B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.186	+2.321	.007	.005	3	1
UCEC	IGFBP2 →	-0.594	-1.584	.011	.019	3	1
UCEC	ACVRL1 →	-0.142	-2.446	.003	.018	3	1
UCEC	JNK2 →	+0.182	+1.584	.011	.019	3	1
UCEC	MEK1 →	+0.277	+1.874	.035	.049	3	1
UCEC	NF2 →	+0.195	+1.874	.012	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ERK2 by ATP1B4 expression — UCEC

Explore this box plot interactively →