ATP1B4

Across TCGA pan-cancer cohorts, ATP1B4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ATP1B4 data layer compared with 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ATP1B4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ATP1B4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and SCLC show a favorable association.

HNSC, DLBC, and BLCA are the cancer types where ATP1B4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.687	0.795	<.001	95	view →
DLBC	DFS	Tertile	All	0.266	0.809	<.001	84	view →
BLCA	OS	Tertile	IV	0.291	0.639	.006	66	view →
SKCM	OS	Median	III,IV	0.497	0.309	.006	44	view →
KIRP	DFS	Tertile	All	0.348	0.740	.001	37	view →
SCLC	DFS	Quartile	All	0.811	0.533	.003	37	view →
THCA	DFS	Tertile	II,III,IV	0.516	0.818	<.001	33	view →
KIRC	DFS	Median	III,IV	0.583	0.823	.006	32	view →
MESO	OS	Quartile	IV	0.336	0.656	.007	31	view →
LUSC	OS	Tertile	All	0.318	0.431	.005	24	view →
SARC	OS	Tertile	All	0.379	0.694	.001	13	view →
STAD	DFS	Tertile	All	0.449	0.588	.023	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ATP1B4–HNSC (OS)

Open the HNSC breakdown →