ATP1B2

Across TCGA patient cohorts, ATP1B2 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP1B2-associated genes across cancer lineages are Tuberin, Gab2, and INPP4B. Each is linked with ATP1B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP1B2-to-partner and partner-to-ATP1B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by ATP1B2-low versus ATP1B2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP1B2→partner) and Y-score (partner→ATP1B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.391	+2.469	.001	.010	3	2
UCEC	Gab2 →	+0.368	+2.000	.022	.032	3	1
UCEC	INPP4B →	-0.329	-2.999	.024	.035	3	1
UCEC	JNK2 →	+0.414	+3.710	<.001	<.001	3	1
UCEC	Ku80 →	+0.283	+3.820	.007	<.001	3	1
UCEC	LKB1 →	-0.140	-2.700	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Tuberin by ATP1B2 expression — UCEC

Explore this box plot interactively →