ATP1B2

Across TCGA pan-cancer cohorts, ATP1B2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ATP1B2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ATP1B2 RNA is repressed in tumor relative to normal tissue. In most cancer types ATP1B2 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and BLCA are the cancer types where ATP1B2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP1B2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	All	−3.360	<.001	11	view →
KICH	Male	IV	−3.210	<.001	11	view →
BLCA	Male	All	−2.174	<.001	11	view →
COAD	Male	All	−1.346	<.001	11	view →
KIRC	Male	II,III,IV	−0.866	<.001	10	view →
LUSC	Female	All	−1.969	<.001	9	view →
UCEC	All	III,IV	−3.718	<.001	8	view →
LUAD	Female	III,IV	−1.677	<.001	8	view →
BRCA	All	All	−1.240	<.001	6	view →
READ	All	All	−1.535	<.001	5	view →
STAD	All	All	−1.234	<.001	5	view →
PRAD	All	All	−0.578	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ATP1B2–KIRP

Open the KIRP breakdown →