ATP1A3

Across TCGA pan-cancer cohorts, ATP1A3 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ATP1A3 data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ATP1A3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ATP1A3 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC and GBM are the cancer types where ATP1A3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.132	1.000	.004	37	view →
GBM	DFS	Tertile	All	0.821	0.636	.012	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

ATP1A3–HNSC (OS)

Open the HNSC breakdown →