ATP1A3

Across TCGA pan-cancer cohorts, ATP1A3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ATP1A3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ATP1A3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATP1A3 is over-expressed in tumor, although a few such as READ and STAD show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where ATP1A3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP1A3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	+0.513	<.001	9	view →
KICH	All	II,III,IV	+3.583	<.001	8	view →
KIRP	All	All	+0.739	.002	7	view →
BRCA	All	III,IV	+1.809	<.001	6	view →
BLCA	All	All	+0.900	.011	5	view →
LUAD	All	All	+0.525	<.001	3	view →
READ	All	All	−1.441	.002	2	view →
LUSC	All	All	+0.331	.010	2	view →
STAD	Female	III,IV	−1.425	.033	1	view →
CHOL	All	All	+0.980	.027	1	view →
COAD	All	All	−0.522	.026	1	view →
LIHC	Female	II,III,IV	+0.237	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ATP1A3–KIRC

Open the KIRC breakdown →