ATP1A3

Across TCGA patient cohorts, ATP1A3 mutation is significantly associated with the RNA expression of many other genes, with 4,037 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP1A3-associated genes across cancer lineages are BUB3, ZNF511, and TSPY26P. Each is linked with ATP1A3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP1A3-to-partner and partner-to-ATP1A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by ATP1A3-low versus ATP1A3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP1A3→partner) and Y-score (partner→ATP1A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	BUB3 →	+0.386	+3.193	.002	.009	3	4
SKCM	ZNF511 →	+0.287	+1.401	<.001	.001	3	4
UCEC	TSPY26P →	-0.551	-2.070	.001	.001	3	4
UCEC	CPE →	-0.873	-1.700	<.001	.001	3	4
UCEC	ZWINT →	+0.586	+1.459	<.001	.001	3	4
HNSC	RNU6-933P →	+0.288	+3.075	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,037 associations by consensus.

BUB3 by ATP1A3 expression — LUSC

Explore this box plot interactively →