ATP1A1

Across TCGA cell cohorts, ATP1A1 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP1A1-associated genes across cancer lineages are USP17L11, MEIKIN, and USP17L20. Each is linked with ATP1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP1A1-to-partner and partner-to-ATP1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L11 grouped by ATP1A1-low versus ATP1A1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP1A1→partner) and Y-score (partner→ATP1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	USP17L11 →	+0.016	+5.415	<.001	.004	3	1
SKIN	MEIKIN →	+0.022	+5.415	<.001	.004	3	1
SKIN	USP17L20 →	+0.016	+5.415	<.001	.004	3	1
SKIN	USP17L18 →	+0.016	+5.415	<.001	.004	3	1
BLOOD_Leukemia	TRIML1 →	+0.021	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TBC1D3H →	+1.023	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

USP17L11 by ATP1A1 expression — SKIN

Explore this box plot interactively →