ATP13A1

Across TCGA cell cohorts, ATP13A1 mutation is significantly associated with the RNA expression of many other genes, with 225 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP13A1-associated genes across cancer lineages are KHDC3L, FAM236A, and MINAR2. Each is linked with ATP13A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP13A1-to-partner and partner-to-ATP13A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KHDC3L grouped by ATP13A1-low versus ATP13A1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP13A1→partner) and Y-score (partner→ATP13A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KHDC3L →	+0.043	+2.974	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	FAM236A →	+0.120	+5.357	<.001	.003	3	2
CNS	MINAR2 →	+0.087	+3.473	<.001	.001	3	2
BLOOD_Leukemia	INSM2 →	+0.182	+4.354	<.001	<.001	3	2
BLOOD_Leukemia	KSR2 →	+0.380	+3.798	<.001	.004	3	2
BLOOD_Leukemia	SOX1 →	+0.344	+3.886	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 225 associations by consensus.

KHDC3L by ATP13A1 expression — OVARY

Explore this box plot interactively →