ATP12A

Across TCGA patient cohorts, ATP12A RNA expression is significantly associated with the go_rna of many other GO terms, with 7,000 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ATP12A-associated GO terms across cancer lineages are Establishment of tissue polarity, Morphogenesis of a polarized epithelium, and Negative regulation of neuron projection development. Each is linked with ATP12A in more than 17 cancer types. Because this analysis shows association rather than direction, both ATP12A-to-partner and partner-to-ATP12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of tissue polarity grouped by ATP12A-low versus ATP12A-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP12A→partner) and Y-score (partner→ATP12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Establishment of tissue polarity →	+0.060	+1.428	<.001	<.001	3	18
STAD	Morphogenesis of a polarized epithelium →	+0.045	+0.258	<.001	<.001	3	15
STAD	Negative regulation of neuron projection development →	+0.059	+0.261	<.001	<.001	2	15
STAD	Protein localization to microtubule →	+0.069	+0.192	<.001	<.001	3	14
STAD	Ephrin receptor signaling pathway →	+0.072	+0.158	<.001	.006	2	15
THYM	Apical protein localization →	+0.084	+0.757	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,000 associations by consensus.

Establishment of tissue polarity by ATP12A expression — ESCA

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