ATP12A

Across TCGA pan-cancer cohorts, ATP12A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ATP12A data layer compared with 8 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ATP12A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ATP12A expression acts as an unfavorable survival marker, although some lineages such as CESC and LIHC show a favorable association.

UVM, CESC, and DLBC are the cancer types where ATP12A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.520	0.844	<.001	133	view →
CESC	DFS	Quartile	All	0.912	0.766	.003	56	view →
DLBC	DFS	Tertile	III,IV	0.074	0.984	.003	56	view →
BLCA	OS	Tertile	IV	0.353	0.872	.002	43	view →
LIHC	DFS	Tertile	All	0.653	0.486	<.001	37	view →
LAML	DFS	Tertile	All	0.599	0.325	.001	36	view →
SKCM	OS	Quartile	All	0.764	0.920	<.001	34	view →
HNSC	DFS	Median	III,IV	0.675	0.507	.001	31	view →
GBM	OS	Median	All	0.274	0.537	<.001	27	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	24	view →
LUSC	DFS	Median	II,III,IV	0.481	0.290	.001	24	view →
UCEC	DFS	Quartile	All	0.628	0.726	.033	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ATP12A–UVM (OS)

Open the UVM breakdown →