ATP12A

Across TCGA patient cohorts, ATP12A mutation is significantly associated with the RNA expression of many other genes, with 6,821 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP12A-associated genes across cancer lineages are SESN2, EXOSC7, and MED8. Each is linked with ATP12A in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP12A-to-partner and partner-to-ATP12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SESN2 grouped by ATP12A-low versus ATP12A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP12A→partner) and Y-score (partner→ATP12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SESN2 →	+0.795	+2.354	<.001	<.001	3	4
BLCA	EXOSC7 →	+0.360	+2.620	.008	.005	3	4
UCEC	MED8 →	+0.368	+2.675	<.001	<.001	3	4
UCEC	FRZB →	-0.690	-1.563	.009	.002	3	4
UCEC	NDRG2 →	-0.925	-1.574	<.001	.002	3	4
UCEC	PLIN3 →	+0.483	+3.764	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,821 associations by consensus.

SESN2 by ATP12A expression — UCEC

Explore this box plot interactively →