ATP12A

Across TCGA cell cohorts, ATP12A mutation is significantly associated with the RNA expression of many other genes, with 222 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP12A-associated genes across cancer lineages are PSMG2, POC1A, and ADH5. Each is linked with ATP12A in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP12A-to-partner and partner-to-ATP12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMG2 grouped by ATP12A-low versus ATP12A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP12A→partner) and Y-score (partner→ATP12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PSMG2 →	+0.533	+3.321	<.001	.003	3	2
LARGE_INTESTINE	POC1A →	+0.433	+3.169	.006	.009	3	2
LARGE_INTESTINE	ADH5 →	+0.524	+2.588	.009	.004	3	2
LUNG_SCLC	MAGEB4 →	+0.004	+4.058	<.001	.007	3	1
LUNG_SCLC	OR11H1 →	+0.065	+4.459	<.001	.001	3	1
LUNG_SCLC	SLC36A3 →	+0.017	+4.169	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 222 associations by consensus.

PSMG2 by ATP12A expression — LARGE_INTESTINE

Explore this box plot interactively →