ATP11B

Across TCGA patient cohorts, ATP11B mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP11B-associated genes across cancer lineages are EGFR_pY1068, EGFR, and eIF4E. Each is linked with ATP11B in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP11B-to-partner and partner-to-ATP11B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ATP11B-low versus ATP11B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP11B→partner) and Y-score (partner→ATP11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.236	-2.415	.003	.002	3	2
UCEC	EGFR →	-0.217	-2.000	<.001	<.001	3	2
UCEC	eIF4E →	+0.179	+2.000	.008	<.001	3	2
UCEC	FoxM1 →	+0.223	+2.000	.007	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.194	-3.000	<.001	<.001	3	2
UCEC	JNK2 →	+0.149	+1.222	.021	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

EGFR_pY1068 by ATP11B expression — UCEC

Explore this box plot interactively →