ATP11A

Across TCGA patient cohorts, ATP11A mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP11A-associated genes across cancer lineages are RAD51, Notch1, and p62 Lck ligand. Each is linked with ATP11A in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP11A-to-partner and partner-to-ATP11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by ATP11A-low versus ATP11A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP11A→partner) and Y-score (partner→ATP11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RAD51 →	+0.252	+3.000	.029	.036	2	3
UCEC	Notch1 →	+0.164	+1.857	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.339	+1.432	<.001	.005	3	2
UCEC	PCNA →	+0.198	+1.432	.001	.005	3	2
UCEC	Shc_pY317 →	-0.157	-1.637	<.001	.001	3	2
UCEC	ATM →	-0.453	-1.637	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

RAD51 by ATP11A expression — STAD

Explore this box plot interactively →