ATP11A

Across TCGA pan-cancer cohorts, ATP11A RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of ATP11A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ATP11A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATP11A is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

COAD, KIRC, and HNSC are the cancer types where ATP11A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP11A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+2.711	<.001	12	view →
KIRC	Female	All	+2.002	<.001	12	view →
HNSC	All	III,IV	+1.009	<.001	11	view →
STAD	Male	II,III,IV	+2.141	<.001	10	view →
KICH	Female	II,III,IV	−2.050	<.001	8	view →
KIRP	All	II,III,IV	+0.968	.001	8	view →
READ	All	All	+2.120	<.001	7	view →
THCA	Female	II,III,IV	+1.333	<.001	7	view →
BLCA	All	All	+0.700	.002	7	view →
LUSC	Female	All	−1.975	<.001	6	view →
LIHC	Female	All	+1.040	<.001	6	view →
BRCA	All	III,IV	−0.636	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

ATP11A–COAD

Open the COAD breakdown →