ATP10B

Across TCGA patient cohorts, ATP10B mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP10B-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and Cyclin-B1. Each is linked with ATP10B in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP10B-to-partner and partner-to-ATP10B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ATP10B-low versus ATP10B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP10B→partner) and Y-score (partner→ATP10B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.426	+1.434	.005	.005	3	3
UCEC	4E-BP1 →	+0.298	+2.392	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.502	+1.362	<.001	.001	3	3
BRCA	eEF2 →	+0.203	+3.174	.041	.010	3	2
UCEC	Caspase-8 →	-0.229	-4.728	<.001	<.001	3	2
BRCA	Chk1_pS345 →	+0.138	+1.700	.036	.046	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Caspase-7-cleavedD198 by ATP10B expression — UCEC

Explore this box plot interactively →