ATP10B

Across TCGA pan-cancer cohorts, ATP10B RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ATP10B data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ATP10B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP10B expression acts as an unfavorable survival marker, although some lineages such as MESO and LAML show a favorable association.

UVM, THCA, and MESO are the cancer types where ATP10B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	III,IV	0.240	1.000	<.001	81	view →
THCA	DFS	Tertile	III,IV	0.568	0.900	.006	47	view →
MESO	DFS	Tertile	All	0.751	0.234	.006	46	view →
LAML	DFS	Tertile	All	0.494	0.280	.004	38	view →
HNSC	OS	Tertile	All	0.838	0.703	.001	31	view →
LGG	OS	Tertile	All	0.720	0.862	<.001	31	view →
COAD	DFS	Tertile	IV	0.598	0.162	.010	30	view →
READ	OS	Median	II,III,IV	1.000	0.445	.002	30	view →
UCEC	DFS	Tertile	All	0.538	0.697	.004	26	view →
KIRP	DFS	Tertile	All	0.869	0.979	.003	26	view →
ESCA	OS	Median	All	0.617	1.000	.009	24	view →
LIHC	OS	Tertile	III,IV	0.431	0.788	.002	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ATP10B–UVM (DFS)

Open the UVM breakdown →