ATP10B

Across TCGA cell cohorts, ATP10B mutation is significantly associated with the mutation status of many other genes, with 3,673 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP10B-associated genes across cancer lineages are DOCK6, ZNF516, and JARID2. Each is linked with ATP10B in more than 4 cancer types. Because this analysis shows association rather than direction, both ATP10B-to-partner and partner-to-ATP10B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DOCK6 grouped by ATP10B-low versus ATP10B-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP10B→partner) and Y-score (partner→ATP10B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DOCK6 →	+2.753	+3.078	.004	.004	1	5
SKIN	ZNF516 →	+4.117	+3.638	.002	.002	1	5
BLOOD_Leukemia	JARID2 →	+2.446	+2.640	<.001	<.001	1	5
LUNG_NSCLC_LUAD	MSH4 →	+3.266	+2.981	.009	.009	1	5
STOMACH	ENAM →	+3.942	+4.584	.002	.002	1	5
OVARY	NCAN →	+3.023	+3.688	.002	.002	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,673 associations by consensus.

DOCK6 by ATP10B expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →