ATOH8

Across TCGA patient cohorts, ATOH8 mutation is significantly associated with the RNA expression of many other genes, with 1,624 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATOH8-associated genes across cancer lineages are RNU6-1214P, MIR668, and RNU6-617P. Each is linked with ATOH8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATOH8-to-partner and partner-to-ATOH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1214P grouped by ATOH8-low versus ATOH8-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATOH8→partner) and Y-score (partner→ATOH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-1214P →	+0.355	+5.306	<.001	.006	3	2
SKCM	MIR668 →	+0.373	+7.816	<.001	.008	3	2
SKCM	RNU6-617P →	+0.338	+7.816	<.001	.008	3	1
SKCM	MIR378F →	+0.488	+7.816	<.001	.008	3	1
UCEC	ARRDC3-AS1 →	+0.347	+3.021	<.001	<.001	3	1
BRCA	RNU6-771P →	+0.383	+8.055	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,624 associations by consensus.

RNU6-1214P by ATOH8 expression — CESC

Explore this box plot interactively →