ATOH8

Across TCGA pan-cancer cohorts, ATOH8 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of ATOH8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ATOH8 RNA is repressed in tumor relative to normal tissue. In most cancer types ATOH8 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and LUSC are the cancer types where ATOH8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATOH8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−2.958	<.001	11	view →
COAD	All	III,IV	−0.869	<.001	11	view →
LUSC	Female	II,III,IV	−4.300	<.001	9	view →
LUAD	Female	II,III,IV	−3.167	<.001	9	view →
HNSC	Male	IV	−1.470	<.001	8	view →
STAD	All	All	−0.948	<.001	8	view →
BLCA	Male	III,IV	−2.735	<.001	7	view →
LIHC	Male	All	−1.172	<.001	7	view →
UCEC	All	III,IV	−2.993	<.001	6	view →
BRCA	All	II,III,IV	−2.648	<.001	6	view →
KIRP	Male	All	−1.350	<.001	6	view →
PAAD	Male	All	−1.279	.046	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

ATOH8–KICH

Open the KICH breakdown →