ATOH8

Across TCGA patient cohorts, ATOH8 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATOH8-associated genes across cancer lineages are eIF4E, FOXO3a_pS318_S321, and MAPK_pT202_Y204. Each is linked with ATOH8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATOH8-to-partner and partner-to-ATOH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ATOH8-low versus ATOH8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATOH8→partner) and Y-score (partner→ATOH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.197	+2.820	.038	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.112	-1.990	.047	.030	3	1
UCEC	MAPK_pT202_Y204 →	-0.488	-3.169	.021	.019	3	1
UCEC	MEK1 →	+0.490	+3.584	.002	.002	3	1
UCEC	mTOR_pS2448 →	-0.171	-3.302	.010	.010	3	1
UCEC	Notch1 →	+0.164	+3.469	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eIF4E by ATOH8 expression — UCEC

Explore this box plot interactively →