ATOH7

Across TCGA pan-cancer cohorts, ATOH7 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ATOH7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ATOH7 RNA is repressed in tumor relative to normal tissue. In most cancer types ATOH7 is over-expressed in tumor, although a few such as KICH and LIHC show the opposite, repressed pattern.

KICH, HNSC, and LIHC are the cancer types where ATOH7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATOH7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−0.598	<.001	10	view →
HNSC	All	II,III,IV	+0.183	<.001	8	view →
LIHC	All	All	−0.182	<.001	7	view →
UCEC	All	II,III,IV	+0.424	.006	6	view →
BRCA	All	III,IV	−0.167	<.001	6	view →
LUSC	Male	All	+0.438	<.001	5	view →
CHOL	All	All	−0.407	.016	4	view →
KIRP	All	II,III,IV	−0.338	.002	4	view →
LUAD	All	All	+0.219	<.001	3	view →
THCA	All	All	+0.123	.008	3	view →
PRAD	All	All	+0.178	<.001	2	view →
COAD	Male	II,III,IV	+0.150	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ATOH7–KICH

Open the KICH breakdown →