ATN1

Across TCGA patient cohorts, ATN1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATN1-associated genes across cancer lineages are eEF2, A-Raf_pS299, and Annexin-1. Each is linked with ATN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATN1-to-partner and partner-to-ATN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ATN1-low versus ATN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATN1→partner) and Y-score (partner→ATN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.296	+1.137	.008	.041	3	2
UCEC	A-Raf_pS299 →	-0.111	-1.584	.003	.032	3	2
UCEC	Annexin-1 →	+0.395	+1.522	.017	.017	3	2
UCEC	Caspase-7-cleavedD198 →	+0.826	+2.584	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.210	-1.502	.007	.027	3	1
UCEC	ERK2 →	+0.179	+1.836	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eEF2 by ATN1 expression — UCEC

Explore this box plot interactively →