ATN1

Across TCGA cell cohorts, ATN1 mutation is significantly associated with the RNA expression of many other genes, with 1,088 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATN1-associated genes across cancer lineages are LAX1, DCANP1, and GUCA1C. Each is linked with ATN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATN1-to-partner and partner-to-ATN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LAX1 grouped by ATN1-low versus ATN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATN1→partner) and Y-score (partner→ATN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LAX1 →	+0.061	+2.714	.006	.002	3	3
PANCREAS	DCANP1 →	+0.006	+4.222	<.001	.002	3	2
URINARY_TRACT	GUCA1C →	+0.341	+3.584	.004	.009	3	2
BLOOD_Leukemia	TLE6 →	+0.993	+3.503	.002	.001	3	2
BREAST	TBX5 →	+0.387	+3.362	.001	.007	3	2
LARGE_INTESTINE	GCH1 →	+0.583	+2.628	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,088 associations by consensus.

LAX1 by ATN1 expression — LARGE_INTESTINE

Explore this box plot interactively →