ATMIN

Across TCGA patient cohorts, ATMIN mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATMIN-associated genes across cancer lineages are ATM, eEF2, and GSK-3_pS9. Each is linked with ATMIN in more than 2 cancer types. Because this analysis shows association rather than direction, both ATMIN-to-partner and partner-to-ATMIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ATMIN-low versus ATMIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATMIN→partner) and Y-score (partner→ATMIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.532	-3.308	.001	.009	3	3
UCEC	eEF2 →	+0.310	+2.321	.021	.033	3	2
UCEC	GSK-3_pS9 →	-0.432	-1.700	.004	.042	3	2
UCEC	mTOR_pS2448 →	-0.154	-3.446	.005	.005	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.590	-2.649	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.672	+2.827	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

ATM by ATMIN expression — UCEC

Explore this box plot interactively →