ATM

Across TCGA pan-cancer cohorts, ATM Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ATM data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in testicular germ cell tumors (TGCT), where higher ATM Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ATM expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

TGCT, HNSC, and STAD are the cancer types where ATM Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
TGCT	OS	Median	III,IV	0.003	1.000	<.001	36	view →
HNSC	OS	Median	III,IV	0.338	0.632	.015	21	view →
STAD	DFS	Median	II,III,IV	0.880	0.622	.012	19	view →
UCEC	DFS	Median	All	0.884	0.589	.005	14	view →
LUSC	DFS	Median	III,IV	0.079	0.751	.024	6	view →
MESO	OS	Median	II,III,IV	0.180	0.560	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ATM–TGCT (OS)

Open the TGCT breakdown →