ATM

Across TCGA pan-cancer cohorts, ATM RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ATM’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ATM RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATM is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where ATM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.861	<.001	11	view →
HNSC	All	III,IV	+0.675	<.001	9	view →
THCA	Male	All	−0.662	<.001	8	view →
LIHC	All	All	+0.331	.001	5	view →
CHOL	All	All	+1.167	<.001	4	view →
UCEC	All	All	−0.823	<.001	4	view →
BRCA	Female	All	−0.274	.006	4	view →
KIRP	All	IV	+0.819	<.001	3	view →
KICH	All	All	−0.707	.001	2	view →
STAD	All	II,III,IV	+0.515	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ATM–KIRC

Open the KIRC breakdown →