ATM

Across TCGA patient cohorts, ATM mutation is significantly associated with the RNA expression of many other genes, with 5,948 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATM-associated genes across cancer lineages are GEMIN4, PTP4A3, and CDCA2. Each is linked with ATM in more than 4 cancer types. Because this analysis shows association rather than direction, both ATM-to-partner and partner-to-ATM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GEMIN4 grouped by ATM-low versus ATM-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATM→partner) and Y-score (partner→ATM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GEMIN4 →	+0.472	+2.584	<.001	<.001	3	5
UCEC	PTP4A3 →	-0.631	-1.137	<.001	<.001	3	5
COAD	CDCA2 →	+0.644	+1.768	<.001	<.001	3	5
UCEC	LINC01936 →	-0.352	-2.093	<.001	<.001	3	5
COAD	KIF20A →	+0.350	+2.249	.001	.005	3	5
COAD	AUNIP →	+0.361	+2.335	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,948 associations by consensus.

GEMIN4 by ATM expression — COAD

Explore this box plot interactively →