ATM

Across TCGA patient cohorts, ATM mutation is significantly associated with the total protein of many other genes, with 109 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATM-associated genes across cancer lineages are Caspase-7-cleavedD198, PRDX1, and PCNA. Each is linked with ATM in more than 5 cancer types. Because this analysis shows association rather than direction, both ATM-to-partner and partner-to-ATM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ATM-low versus ATM-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATM→partner) and Y-score (partner→ATM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.058	+1.523	<.001	.009	3	6
BLCA	PRDX1 →	+0.263	+1.392	<.001	.013	3	5
COAD	PCNA →	+0.227	+2.459	.002	.017	3	5
UCEC	Cyclin-B1 →	+0.465	+1.688	<.001	<.001	3	5
LUAD	Caveolin-1 →	-0.850	-2.321	.014	.035	3	4
COAD	Rictor →	-0.819	-2.222	.007	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 109 associations by consensus.

Caspase-7-cleavedD198 by ATM expression — COAD

Explore this box plot interactively →